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KMID : 1035620160040060423
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Allergy Asthma & Respiratory Disease
2016 Volume.4 No. 6 p.423 ~ p.428
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Association between the serum 25-hydroxyvitamin D level and allergic rhinitis in Korean children
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Yoon Seo-Hee
Kim Jung-Yoon
Kim Yoon-Hee
Park Young-A
Sol In-Suk
Kim Min-Jung
Kim Kyung-Won
Sohn Myung-Hyun
Kim Kyu-Earn
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Abstract
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Purpose : Vitamin D is known to play an important role in the regulation of the immune system and in the prevention of allergic disease. Herein, we examined the association between vitamin D and allergic rhinitis (AR) in children.
Methods : A total of 72 aeroallergen-proven AR and 57 healthy control subjects who visited Severance Children's Hospital between 2012 and 2014 were evaluated. The mean serum 25-hydroxyvitamin D (25(OH)D) level was measured in all subjects to evaluate their vitamin D status.
Results : The mean serum 25(OH)D levels was significantly lower in patients with AR than in controls (19.5±6.4 ng/mL vs. 22.3±5.8 ng/mL, P=0.013). The incidence of AR is higher in the 25(OH)D-insufficient group (15?20 ng/mL) and in the 25(OH)D-deficient group (≤15 ng/mL) compared with the 25(OH)D-sufficient group (>20 ng/mL) (40.3% vs. 84.4% vs. 22.2%, P<0.001). There was no significant difference in the serum 25(OH)D level between subgroups with mild and moderate-to-severe AR symptoms (19.8±6.5 vs. 19.0±6.3, P=0.596). After adjusting for confounding factors, the lower serum vitamin D level groups had increased odds of AR compared with the 25(OH)D-sufficient group (odds ration [95% confidence interval]; 3.67 [1.29?10.38] in the 25(OH)D-insufficient group; P=0.014 and 6.04 [1.49?24.51] in the 25(OH)D-deficient group; P=0.012).
Conclusion : The serum vitamin D levels were significantly lower in children with AR compared with healthy controls. Therefore, lower serum level of 25(OH)D may be associated with the development of AR.
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KEYWORD
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Allergic rhinitis, Vitamin D, Childhood
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